UbiProt Database - proteins_show

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Protein information

Protein name DNA-directed RNA polymerase II largest subunit 
Synonyms RNA polymerase II subunit 1
EC 2.7.7.6
B220
Gene name YDL140C , SUA8 , RPO21 , RPB220 , RPB1 , D2150 .
Source Saccharomyces cerevisiae (Baker's yeast)
Expression system Saccharomyces cerevisiae (Baker's yeast)
Full length  1733
Precursor  no
Mature form length  1733
Molecular weight (Da)  191612
Swiss-Prot Sequence Version  November 1, 1997 (Sequence version 2)

Cross-references

Swiss-Prot/TrEMBL RPB1_YEAST
PDB 1Y77 , 1Y1Y , 1Y1V , 1WCM , 1TWH , 1TWG , 1TWF , 1TWC , 1TWA , 1SFO , 1R9T , 1R9S , 1R5U , 1PQV , 1NT9 , 1NIK , 1K83 , 1I6H , 1I50 , 1I3Q .

Ubiquitylation features

Ubiquitylation site K695 [4]
 

Ubiquitylation type Not Determined
Features Not determined

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Rsp5 [1, 2]
E4/AP Not determined
DUB Not determined
Comments Not determined

References

[1]Beaudenon SL, Huacani MR, Wang G, McDonnell DP, Huibregtse JM
Rsp5 Ubiquitin-Protein Ligase Mediates Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae. Mol.Cell.Biol. 1999, 19:6972-6979.
[10490634]
[2]Huibregtse JM, Yang JC, Beaudenon SL:
The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase. Proc.Natl.Acad.Sci U.S.A 1997, 94:3656-3661.
[9108033]
[3]Mayor T, Russell L. J., Graumann J., Smith G. T., Deshaies R. J.:
Analysis of poly-ubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets. Mol Cell Proteomics 2005 4(6):741-751
[15699485]
[4]Hitchcock AL, Auld K, Gygi SP, Silver PA.
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc.Natl.Acad.Sci U.S.A 2003, 100:12735-12740.
[14557538]
 

Ubiquitylation type Multiple ubiquitylation
Features Not determined

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Rsp5 [1]
E4/AP Not determined
DUB Not determined
Comments Not determined

References

[1]Kus B, Gajadhar A, Stanger K, Cho R, Sun W, Rouleau N, Lee T, Chan D, Wolting C, Edwards A, Bosse R, Rotin D:
A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. J.Biol.Chem. 2005, 280:29470-29478.
[15955809]

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