UbiProt Database - proteins_show

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Protein information

Protein name NF-kappa-B essential modulator 
Synonyms NEMO
NF-kappa-B essential modifier
Inhibitor of nuclear factor kappa-B kinase gamma subunit
IkB kinase gamma subunit
I-kappa-B kinase gamma
IkB kinase-associated protein 1
Gene name IKBKG , FIP3 , NEMO .
Source Homo sapiens (Human)
Expression system Human Jurkat T cells
Full length  419
Precursor  no
Mature form length  419
Molecular weight (Da)  48198
Swiss-Prot Sequence Version  May 30, 2000 (Sequence version 2)
Comments  Activation of the "classical" NF-k B pathway converges on the Ik B kinase (IKK) signalosome, a protein complex composed of two kinase subunits (IKK-a and IKK-b) and a non-catalytic subunit NF-k B essential modulator (NEMO)



Ubiquitylation features

Ubiquitylation site K399

Ubiquitylation type Lys63-linked multi-ubiquitin chain
Features The adaptor protein Bcl10 promotes activation of NF-k B transcription factors by T- and B-cell receptors through paracaspase-and UBC13-dependent ubiquitination of NEMO.

Ubiquitylation/deubiquitylation machinery

E2 E2 complex UBC13-MMS2
E3 Paracaspase
E4/AP Bcl10
DUB Not determined
Comments Paracaspase lacks a RING or HECT domain normally found in ubiquitin ligases, but instead uses its C-terminal caspase-like domain to catalyse ubiquitination


[1]Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit V.M:
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 2004, 427:167-171


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