UbiProt Database - proteins_show

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Protein information

Protein name Probable histone-lysine N-methyltransferase ASH1L 
Synonyms EC 2.1.1.43
ASH1-like protein
Absent small and homeotic disks protein 1 homolog
huASH1
Lysine N-methyltransferase 2H
Gene name ASH1L , KIAA1420 , KMT2H .
Source Homo sapiens (Human)
Expression system H1299 cells transfected with anti-VCP siRNA
Full length  2969
Precursor  no
Mature form length  2969
Molecular weight (Da)  332790
Swiss-Prot Sequence Version  October 31, 2006 (Sequence version 2)
Comments  ASH1L is a histone methyltransferase that probably methylates Lys4 of histone H3, a specific tag for epigenetic transcriptional activation.

Cross-references

Swiss-Prot/TrEMBL ASH1L_HUMAN
PDB 1PEG .

Ubiquitylation features

Ubiquitylation site K402, K406
 

Ubiquitylation type Not Determined
Features Ubiquitylation sites were determined by mass spectrometry. Signature peptide - KIVASSAMGLVNKggDIGKggK.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Not determined
E4/AP Not determined
DUB Not determined
Comments -

References

[1]Vasilescu J, Zweitzig DR, Denis NJ, Smith JC, Ethier M, Haines DS, Figeys D.
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. J. Proteome Res. 6:298-305 (2007).
[17203973]

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