UbiProt Database - proteins_show

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Protein information

Protein name COMM domain-containing protein 1 
Synonyms Protein Murr1
Gene name COMMD1 , C2orf5 , MURR1 .
Source Homo sapiens (Human)
Expression system HEK293
Full length  190
Precursor  no
Mature form length  190
Molecular weight (Da)  21178
Swiss-Prot Sequence Version  October 1, 2002 (Sequence version 1)
Comments  MURR1 is involved in the regulation of copper homeostasis in mammals and of NF-kappaB pathway.


PDB 2H2M .

Ubiquitylation features

Ubiquitylation site  

Ubiquitylation type Multiple ubiquitylation

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E4/AP Not determined
DUB Not determined
Comments XIAP modifies MURR1 wtith K48-linked multiubiquitin chains, targeting MURR1 for proteasomal degradation. An unknown ligase also catalyses K48-independent multiubiquitylation of MURR1. BIR3 domain of XIAP is necessary and sufficient for MURR1 binding. This interaction does not affect XIAP anti-apoptotic function.


[1]Burstein E, Ganesh L, Dick RD, van De Sluis B, Wilkinson JC, Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS.
A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J. 23(1):244-54 (2004).


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