UbiProt Database - proteins_show

UbiProt database V 1.0

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Protein information

Protein name Histone-lysine N-methyltransferase HRX 
Synonyms ALL-1
Trithorax-like protein
Zinc finger protein HRX
Lysine N-methyltransferase 2A
CXXC-type zinc finger protein 7
Gene name MLL , ALL1 , HRX , HTRX , TRX1 , CXXC7 , KMT2A .
Source Homo sapiens (Human)
Expression system H1299 cells transfected with an empty vector
Full length  3969
Precursor  no
Mature form length  3969
Molecular weight (Da)  431764
Swiss-Prot Sequence Version  May 1, 2007 (Sequence version 5)
Comments  Nuclear protein. Transcriptional regulator. Phosphorylated. 2 isoforms.


PDB 2AGH , 2J2S .

Ubiquitylation features

Ubiquitylation site K216, K220, K221

Ubiquitylation type Not Determined
Features Ubiquitylation was demonstrated for isoform 1 of the protein by mass spectrometry. Signature peptide - DSKggSIEKlrggKggR.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Not determined
E4/AP Not determined
DUB Not determined
Comments -


[1]Vasilescu J, Zweitzig DR, Denis NJ, Smith JC, Ethier M, Haines DS, Figeys D.
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. J. Proteome Res. 6:298-305 (2007).


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