UbiProt Database - proteins_show

UbiProt database V 1.0

[Main] [Search] [View all proteins] [Submit new protein] [Help] [Contacts] [VSDocker] [UbIdent]

Protein information

Protein name Baculoviral IAP repeat-containing protein 4 
Synonyms Inhibitor of apoptosis protein 3
X-linked inhibitor of apoptosis protein
X-linked IAP
IAP-like protein
Gene name BIRC4 , API3 , IAP3 , XIAP .
Source Homo sapiens (Human)
Expression system 2B4.11 T hybridoma cells
Full length  497
Precursor  no
Mature form length  497
Molecular weight (Da)  56685
Swiss-Prot Sequence Version  January 24, 2001 (Sequence version 2)
Comments  Autoubiquitylation


PDB 1C9Q , 1F9X , 1G3F , 1G73 , 1I3O , 1I4O , 1I51 , 1KMC , 1NW9 , 1TFQ .

Ubiquitylation features

Ubiquitylation site K322; K328 [1]

Ubiquitylation type Not Determined
Features In vitro ubiquitination reaction was carried out by adding recombinant wheat E1 [2].

Ubiquitylation/deubiquitylation machinery

E2 UbcH5b [2].
E3 Not determined
E4/AP Not determined
DUB Not determined
Comments In vitro an in vivo [2].


[1]Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS:
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J 2003, 373:965-971.
[2]Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD:
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 2000, 288:874-877.


.: Curator Access :.
Login: Password: