UbiProt Database - proteins_show

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Protein information

Protein name C-X-C chemokine receptor type 4 
Synonyms CXC-R4
CXCR-4
Stromal cell-derived factor 1 receptor
SDF-1 receptor
Fusin
Leukocyte-derived seven transmembrane domain receptor
LESTR
LCR1
FB22
NPYRL
HM89
CD184 antigen
Gene name CXCR4 .
Source Homo sapiens (Human)
Expression system HEK293
Full length  352
Precursor  no
Mature form length  352
Molecular weight (Da)  39746
Swiss-Prot Sequence Version  April 26, 2004 (Sequence version 1)

Cross-references

Swiss-Prot/TrEMBL CXCR4_HUMAN
PDB  

Ubiquitylation features

Ubiquitylation site Not determined
 

Ubiquitylation type Not Determined
Features CXCR4-dependent interaction between endocytic proteins Vps4 and Hrs may in part regulate the ubiquitylation status of both Hrs and CXCR4. Ubiquitylation of Hrs is also CXCR4 dependent and mediated by AIP4 ligase.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 AIP4
E4/AP Not determined
DUB Not determined
Comments AIP4 is a HECT-domain ligase and belongs to Nedd4 ligase family.

References

[1]Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL.
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell. 5(5):709-22 (2003).
[14602072]

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