UbiProt Database - proteins_show

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Protein information

Protein name Homeobox protein CUP9 
Gene name CUP9 , YPL177C .
Source Saccharomyces cerevisiae (Baker's yeast)
Expression system Saccharomyces cerevisiae (Baker's yeast)
Full length  306
Precursor  no
Mature form length  306
Molecular weight (Da)  34654
Swiss-Prot Sequence Version  November 1, 1995 (Sequence version 1)


PDB 1B8I .

Ubiquitylation features

Ubiquitylation site ND

Ubiquitylation type Not Determined
Features Imported dipeptides bind to Ubr1 and accelerate the Ubr1-dependent degradation of Cup9, thereby positive feedback circuit was shown [2]

Ubiquitylation/deubiquitylation machinery

E2 UBC2 / RAD6, UBC4
E4/AP Not determined
DUB Not determined
Comments Not determined


[1]Byrd C, Turner GC, Varshavsky A
The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J. 1998, 17:269-277.
[2]Turner GC, Du F, Varshavsky A
Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway. Nature 2000, 405:579-583.


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