UbiProt Database - proteins_show

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Protein information

Protein name Extracellular matrix protein 21 
Synonyms Extracellular mutant protein 21
Gene name YBL101C , YBL0814 , ECM21 .
Source Saccharomyces cerevisiae (Baker's yeast)
Expression system Saccharomyces cerevisiae (Baker's yeast)
Full length  1117
Precursor  no
Mature form length  1117
Molecular weight (Da)  123610
Swiss-Prot Sequence Version  March 1, 2005 (Sequence version 2)

Cross-references

Swiss-Prot/TrEMBL ECM21_YEAST
PDB  

Ubiquitylation features

Ubiquitylation site K577, K651, K712, K794, K807, K1024
 

Ubiquitylation type Not Determined
Features This ubiquitylated protein was isolated uniquely from cells lacking Rpn10 (poly-ubiquitin receptor of 26S proteasome), suggesting that it usually undergoes rapid protesomal degradation [3].

Ubiquitylation/deubiquitylation machinery

E2 UBC4_YEAST+UBC5_YEAST
E3 RSP5_YEAST
E4/AP Not determined
DUB Not determined
Comments Ubiquitilation sites are K577, K651, K712, K794, K807, K1024 [1]; or K577 [2]

References

[1]Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
A proteomics approach to understanding protein ubiquitination. Nat.Biotechnol. 2003, 21:921-926.
[12872131]
[2]Hitchcock AL, Auld K, Gygi SP, Silver PA.
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc.Natl.Acad.Sci U.S.A 2003, 100:12735-12740.
[14557538]
[3]Mayor T, Russell L. J., Graumann J., Smith G. T., Deshaies R. J.:
Analysis of poly-ubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets. Mol Cell Proteomics 2005 4(6):741-751
[15699485]
 

Ubiquitylation type Lys63-linked multi-ubiquitin chain
Features ND

Ubiquitylation/deubiquitylation machinery

E2 ND
E3 RSP5_YEAST
E4/AP ND
DUB ND
Comments ND

References


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