UbiProt Database - proteins_show

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Protein information

Protein name Ubiquitin carboxyl-terminal hydrolase 6 
Synonyms EC
Ubiquitin thioesterase 6
Ubiquitin-specific-processing protease 6
Deubiquitinating enzyme 6
Proto-oncogene TRE-2
Gene name USP6 , Synonyms: HRP1, TRE2 .
Source Homo sapiens (Human)
Expression system HeLa
Full length  1406
Precursor  no
Mature form length  1406
Molecular weight (Da)  158658
Swiss-Prot Sequence Version  July 19, 2004 (Sequence version 2)
Comments  This protein has 3 isoforms. The shortest isoform does not show deubiquitylating activity and is oncogenic.



Ubiquitylation features

Ubiquitylation site  

Ubiquitylation type Multiple ubiquitylation
Features Ubiquitylation of TRE17 is promoted by calcium/calmodulin binding. Treatment with the CaM inhibitor W7 reduces levels of TRE17 monoubiquitylation. The calcium ionophore A23187 induces accumulation of multi-ubiquitylated TRE17 forms. The effect of A23187 is attenuated in CaM binding-deficient mutants of TRE17.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Not determined
E4/AP Not determined
Comments TRE17 promotes its own deubiquitylation in vivo.


[1]Shen C, Ye Y, Robertson SE, Lau AW, Mak DO, Chou MM.
Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. J Biol Chem. 280(43):35967-73 (2005).


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