UbiProt Database - proteins_show

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Protein information

Protein name Carboxypeptidase S 
Synonyms EC 3.4.17.4
YSCS
GLY-X carboxypeptidase
Gene name CPS1 , CPS , YJL172W , J0510 .
Source Saccharomyces cerevisiae (Baker's yeast)
Expression system Saccharomyces cerevisiae (Baker's yeast)
Full length  576
Precursor  no
Mature form length  576
Molecular weight (Da)  64597

Cross-references

Swiss-Prot/TrEMBL CBPS_YEAST
PDB  

Ubiquitylation features

Ubiquitylation site  
 

Ubiquitylation type Multiple ubiquitylation
Features ND

Ubiquitylation/deubiquitylation machinery

E2 UBC4_YEAST
E3 TUL1_YEAST
E4/AP UBP4_YEAST
DUB ND
Comments ND

References

[1]Reggiori F, Pelham HR.
A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Nat.Cell Biol. 2002, 4:117-123.
[11788821]
[2]Reggiori F, Pelham HRB.
Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J. 2001, 20:5176-5186.
[11566881]
[3]Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ
Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway. Mol Cell Proteomics. 6(11):1885-95 (2007)
[17644757]
 

Ubiquitylation type Mono-ubiqutylation
Features ND

Ubiquitylation/deubiquitylation machinery

E2 ND
E3 RSP5_YEAST
E4/AP ND
DUB ND
Comments ND

References

[1]Katzmann DJ, Sarkar S, Chu T, Audhya A, Emr SD.
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Mol.Biol.Cell 2004, 15:468-480.
[14657247]
[2]Morvan J, Froissard M, Haguenauer-Tsapis R, Urban-Grimal D.
The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodies. Traffic. 2004 May;5(5):383-92.
[15086787]
[3]Sullivan JA, Lewis MJ, Nikko E, Pelham HR.
Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro. Mol.Biol.Cell 2007, 18:2429-2440.
[17429078]
[4]Hettema EH, Valdez-Taubas J, Pelham HR:
Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. EMBO J 2004, 23:1279-1288.
[14988731]

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