UbiProt Database - proteins_show

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Protein information

Protein name G1/S-specific cyclin CLN2 
Synonyms  
Gene name CLN2 , YPL256C .
Source Saccharomyces cerevisiae (Baker's yeast)
Expression system Saccharomyces cerevisiae (Baker's yeast)
Full length  545
Precursor  no
Mature form length  545
Molecular weight (Da)  61697
Swiss-Prot Sequence Version  February 1, 1996 (Sequence version 2)

Cross-references

Swiss-Prot/TrEMBL CG12_YEAST
PDB  

Ubiquitylation features

Ubiquitylation site  
 

Ubiquitylation type Lys48-linked multi-ubiquitin chain
Features ND

Ubiquitylation/deubiquitylation machinery

E2 UBC3_YEAST [2,3]
E3 SCF(GRR1) [1,4,5,6], SCF(CDC4) [7]
E4/AP ND
DUB ND
Comments ND

References

[1]Petroski,M.D.; Deshaies,R.J.:
Function and regulation of cullin-RING ubiquitin ligases; Nat.Rev.Mol Cell Biol., 2005, 6, 1, 9-20
[15688063]
[2]Deshaies RJ, Chau V, Kirschner M.
Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 1995 Jan 16;14(2):303-12.
[7835341]
[3]Meimoun A, Holtzman T, Weissman Z, McBride HJ, Stillman DJ, Fink GR, Kornitzer D
Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex. Mol Biol.Cell 2000, 11:915-927.
[10712509]
[4]Berset C, Griac P, Tempel R, La Rue J, Wittenberg C, Lanker S.
Transferable domain in the G(1) cyclin Cln2 sufficient to switch degradation of Sic1 from the E3 ubiquitin ligase SCF(Cdc4) to SCF(Grr1). Mol Cell Biol. 2002 Jul;22(13):4463-76.
[12052857]
[5]Barral Y, Jentsch S, Mann C.
G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev. 1995 Feb 15;9(4):399-409.
[7883165]
[6]Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW.
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell. 1997 Oct 17;91(2):209-19.
[9346238]
[7]Willems AR, Goh T, Taylor L, Chernushevich I, Shevchenko A, Tyers M.
SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1533-50.
[10582239]

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