UbiProt Database - proteins_show

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Protein information

Protein name Retinoic acid receptor alpha 
Synonyms Nuclear receptor subfamily 1 group B member 1
RAR-alpha
Gene name RARA (NR1B1) .
Source Homo sapiens (Human)
Expression system HeLa
Full length  462
Precursor  no
Mature form length  462
Molecular weight (Da)  50771
Swiss-Prot Sequence Version  October 1, 1989 (Sequence version 2)

Cross-references

Swiss-Prot/TrEMBL RARA_HUMAN
PDB 1DKF , 1DSZ .

Ubiquitylation features

Ubiquitylation site Not determined
 

Ubiquitylation type Not Determined
Features Phosphorylation of Thr181, Ser445, and Ser461 by JNK kinase is required for efficient ubiquitylation and subsequent proteasomal degradation of RARa. This process is induced by UV irradiation. Stress-induced RARa protein loss is blocked by proteasome inhibitors.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Not determined
E4/AP Not determined
DUB Not determined
Comments

References

[1]Srinivas H, Juroske DM, Kalyankrishna S, Cody DD, Price RE, Xu XC, Narayanan R, Weigel NL, Kurie JM.
c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha. Mol Cell Biol. 25(3):1054-69 (2005).
[15657432]

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