UbiProt Database - proteins_show

UbiProt database V 1.0

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Protein information

Protein name Neurogenic locus protein delta 
Gene name Dl .
Source Drosophila melanogaster (Fruit fly)
Full length  833
Precursor  yes
Mature form length  815
Molecular weight (Da)  88841
Swiss-Prot Sequence Version  December 1, 2000 (Sequence version 2)



Ubiquitylation features

Ubiquitylation site Not determined

Ubiquitylation type Not Determined
Features Ubiquitylation results in endocytosis and subsequent degradation of Delta.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Neuralized (see Ref. 1), Mind bomb (Refs. 1,2,3)
E4/AP Not determined
DUB Not determined


[1]Lai EC, Deblandre GA, Kintner C, Rubin GM.
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Dev Cell. 1(6):783-94 (2001).
[2]Lai EC, Roegiers F, Qin X, Jan YN, Rubin GM.
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development. 132(10):2319-32 (2005).
[3]Le Borgne R, Remaud S, Hamel S, Schweisguth F.
Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 3(4):e96 (2005).


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