UbiProt Database - proteins_show

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Protein information

Protein name High affinity nerve growth factor receptor 
Synonyms EC 2.7.10.1
Neurotrophic tyrosine kinase receptor type 1
TRK1 transforming tyrosine kinase protein
p140-TrkA
Trk-A
Gene name NTRK1 (TRK) .
Source Homo sapiens (Human)
Expression system HEK293, PC12
Full length  796
Precursor  no
Mature form length  764
Molecular weight (Da)  87497
Swiss-Prot Sequence Version  May 2, 2006 (Sequence version 4)

Cross-references

Swiss-Prot/TrEMBL NTRK1_HUMAN
PDB 1HE7 , 1SHC , 1WWA , 1WWW .

Ubiquitylation features

Ubiquitylation site K485 (K482 according to Swiss-Prot sequence)
 

Ubiquitylation type Lys63-linked multi-ubiquitin chain
Features K63-linked polyubiquitylation in response to nerve growth factor binding regulates receptor endocytosis and signaling.

Ubiquitylation/deubiquitylation machinery

E2 UbcH7
E3 TRAF6
E4/AP Not determined
DUB Not determined
Comments TRAF6 and UbcH7 exist as a complex prior to NGF stimulation and are recruited together to the TrkA receptor upon addition of NGF.

References

[1]Geetha T, Jiang J, Wooten MW.
Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol Cell. 20(2):301-12 (2005).
[16246731]

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