Failure of a dominant negative UbcH7 to inhibit transducin beta-gamma ubiquitylation argues against an essential role for UbcH7 in transducin beta-gamma ubiquitylation, although data do not exclude the possibility that UbcH7 participates with UbcH5 in a combinatorial mechanism
The primary recognition determinants for transducin beta-gamma ubiquitylation appear to reside on transducin beta. Transducin beta-gamma association with phosducin blocks transducin beta-gamma ubiquitylation and subsequent degradation. Transducin gamma species containin not more than four ubiquitin moieties, with monoubiquitylated species predominating
Obin M, Lee BY, Meinke G, Bohm A, Lee RH, Gaudet R, Hopp JA, Arshavsky VY, Willardson BM, Taylor A
Ubiquitylation of the transducin beta gamma subunit complex: Regulation by phosducin. J.Biol.Chem. 2002, 277:44566-44575.