UbiProt Database - proteins_show

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Protein information

Protein name T-cell surface glycoprotein CD4 
Synonyms T-cell surface antigen T4/Leu-3
Gene name CD4 .
Source Homo sapiens (Human)
Full length  458
Precursor  yes
Mature form length  433
Molecular weight (Da)  51111
Swiss-Prot Sequence Version  November 1, 1988 (Sequence version 1)

Cross-references

Swiss-Prot/TrEMBL CD4_HUMAN
PDB 1CDH , 1CDI , 1CDJ , 1CDU , 1CDY , 1G9M , 1G9N , 1GC1 , 1Q68 , 1RZJ , 1RZK , 1WIO , 1WIP , 1WIQ , 2B4C , 3CD4 .

Ubiquitylation features

Ubiquitylation site  
 

Ubiquitylation type Not Determined
Features Not determined

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 SCF(?-TrCP1)
E4/AP Not determined
DUB Not determined
Comments SCF(?-TrCP1) is a Cullin-RING ligase. Cullin component - Cul1, receptor - ?-TrCP1 and 2(FBW1, HOS). HIV Vpu also can serve as a receptor component of the ligase.

References

[1]Petroski,M.D.; Deshaies,R.J.:
Function and regulation of cullin-RING ubiquitin ligases; Nat.Rev.Mol Cell Biol., 2005, 6, 1, 9-20
[15688063]

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