UbiProt Database - proteins_show

UbiProt database V 1.0

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Protein information

Protein name Proto-oncogene protein c-Fos 
Synonyms Cellular oncogene fos
G0/G1 switch regulatory protein 7
v-fos FBJ osteosarcoma oncogene homologue
Gene name FOS , G0S7 .
Source Homo sapiens (Human)
Expression system H1299 cells transfected with anti-VCP siRNA
Full length  380
Precursor  no
Mature form length  380
Molecular weight (Da)  40695
Swiss-Prot Sequence Version  July 21, 1986 (Sequence version 1)
Comments  c-Fos is a nuclear phosphoprotein that is able to form heterodimer with c-Jun - AP-1 transcriptional factor. AP-1 plays an important role in signal transduction, cell proliferation and differentiation.


PDB 1A02 , 1FOS , 1S9K .

Ubiquitylation features

Ubiquitylation site K113

Ubiquitylation type Not Determined
Features Ubiquitylation site was revealed by mass spectrometry. Signature peptide - AGVVKggTMTGGRAQSIGRR.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Not determined
E4/AP Not determined
DUB Not determined
Comments -


[1]Vasilescu J, Zweitzig DR, Denis NJ, Smith JC, Ethier M, Haines DS, Figeys D.
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. J. Proteome Res. 6:298-305 (2007).


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