UbiProt Database - proteins_show

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Protein information

Protein name Carboxypeptidase Y [Precursor]  
Synonyms EC 3.4.16.5
Carboxypeptidase YSCY
Gene name PRC1 , YMR297W .
Source Saccharomyces cerevisiae (Baker's yeast)
Expression system Saccharomyces cerevisiae (Baker's yeast)
Full length  532
Precursor  no
Mature form length  0
Molecular weight (Da)  59802

Cross-references

Swiss-Prot/TrEMBL CBPY_YEAST
PDB  

Ubiquitylation features

Ubiquitylation site  
 

Ubiquitylation type Not Determined
Features ND

Ubiquitylation/deubiquitylation machinery

E2 UBC6+UBC7
E3 HRD1_YEAST
E4/AP ND
DUB ND
Comments ND

References

[1]Taxis C, Hitt R, Park SH, Deak PM, Kostova Z, Wolf DH.
Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J.Biol.Chem. 2003, 278:35903-35913.
[12847107]
[2]Bordallo J, Plemper RK, Finger A, Wolf DH.
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol.Cell 1998, 9:209-222.
[9437001]
[3]Kostova Z, Wolf DH.
For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J. 2003, 22:2309-2317.
[12743025]
[4]Plemper RK, Wolf DH:
Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome. Mol.Biol.Rep. 1999, 26:125-130.
[10363658]
 

Ubiquitylation type Lys48-linked multi-ubiquitin chain
Features ND

Ubiquitylation/deubiquitylation machinery

E2 UBC4_YEAST+UBC5_YEAST [2]
E3 RSP5_YEAST [1]
E4/AP ND
DUB ND
Comments ND

References

[1]Haynes CM, Caldwell S, Cooper AA.
An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. J Cell Biol. 158(1):91-101 (2002)
[12105183]
[2]Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH.
The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol.Biol.Cell 2007, 18:153-165.
[17065559]

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