UbiProt Database - proteins_show

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Protein information

Protein name Epidermal growth factor receptor 
Synonyms EC 2.7.10.1
Receptor tyrosine-protein kinase ErbB-1
Gene name EGFR , ERBB1 .
Source Homo sapiens (Human)
Expression system PAE cells (porcine)
Full length  1210
Precursor  yes
Mature form length  1186
Molecular weight (Da)  134277
Swiss-Prot Sequence Version  November 1, 1997 (Sequence version 2)
Comments  Ubiquitylation is essential for EGFR internalization and endocytosis. Several components of endocytic machinery (like ESCRT) recognize EGFR only in ubiquitylated form. Ubiquitin conjugation sites are located in the kinase domain of EGFR.

Cross-references

Swiss-Prot/TrEMBL EGFR_HUMAN
PDB 2GS2 .

Ubiquitylation features

Ubiquitylation site K716, K737, K754, K867, K929, K970
 

Ubiquitylation type Pluri-ubiquitylation
Features  

Ubiquitylation/deubiquitylation machinery

E2 UbcH7
E3 c-Cbl
E4/AP Not determined
DUB Not determined
Comments

References

[1]Huang F., Kirkpatrick D., Jiang X., Gygi S., Sorkin A.
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 21:737-748(2006).
[16543144]
 

Ubiquitylation type Lys63-linked multi-ubiquitin chain
Features  

Ubiquitylation/deubiquitylation machinery

E2 UbcH7
E3 c-Cbl
E4/AP Not determined
DUB Not determined
Comments

References

[1]Huang F., Kirkpatrick D., Jiang X., Gygi S., Sorkin A.
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 21:737-748(2006).
[16543144]
 

Ubiquitylation type Lys48-linked multi-ubiquitin chain
Features  

Ubiquitylation/deubiquitylation machinery

E2 UbcH7
E3 c-Cbl
E4/AP Not determined
DUB Not determined
Comments

References

[1]Huang F., Kirkpatrick D., Jiang X., Gygi S., Sorkin A.
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 21:737-748(2006).
[16543144]
 

Ubiquitylation type Lys11-linked multi-ubiquitin chain
Features  

Ubiquitylation/deubiquitylation machinery

E2 UbcH7
E3 c-Cbl
E4/AP Not determined
DUB Not determined
Comments

References

[1]Huang F., Kirkpatrick D., Jiang X., Gygi S., Sorkin A.
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 21:737-748(2006).
[16543144]

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