UbiProt Database - proteins_show

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Protein information

Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 
Synonyms EC
HMG-CoA reductase
Gene name HMGCR .
Source Cricetulus griseus (Chinese hamster)
Expression system CHO, LP-90
Full length  887
Precursor  no
Mature form length  887
Molecular weight (Da)  97081
Swiss-Prot Sequence Version  July 21, 1986 (Sequence version 1)
Comments  HMGR is an enzyme of sterol biosynthetic pathway. Transmembrane ER-associated glycoprotein, catalitically active in homodimeric form.



Ubiquitylation features

Ubiquitylation site  

Ubiquitylation type Multiple ubiquitylation
Features Multiubiquitylation of HMGR leads to its proteasomal degradation. Ubiquitylation is enhanced by sterols and high concentrations of mevalonate (a product of HMGR-catalyzed reaction).

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Not determined
E4/AP Not determined
DUB Not determined
Comments Ubiquitylation is most likely facilitated by a membrane-bound UPL.


[1]Ravid T, Doolman R, Avner R, Harats D, Roitelman J.
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 275(46):35840-7 (2000).


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