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Protein information

Protein name Cell death activator CIDE-A 
Synonyms Cell death-inducing DFFA-like effector A
Cidea
Gene name CIDEA .
Source Homo sapiens (Human)
Expression system HEK293T, CHO-K1, H1299
Full length  219
Precursor  no
Mature form length  219
Molecular weight (Da)  24687
Swiss-Prot Sequence Version  August 1, 1998 (Sequence version 1)
Comments  Cidea plays a critical role in thermoregulation and fat accumulation. Cidea overexpression induces apoptosis.

Cross-references

Swiss-Prot/TrEMBL CIDEA_HUMAN
PDB 2EEL .

Ubiquitylation features

Ubiquitylation site  
 

Ubiquitylation type Multiple ubiquitylation
Features Cidea is multi-ubiquitylated and targeted for proteasomal degradation. Proteasome inhibitors cause accumulation of modified Cidea. Both N- and C-terminal lysines can be ubiquitylated, but Lys23 plays a major role in the protein stability regulation.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 Not determined
E4/AP Not determined
DUB Not determined
Comments

References

[1]Chan SC, Lin SC, Li P.
Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway. Biochem J. 2007 Aug 21 [Epub ahead of print]
[17711404]

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