UbiProt Database - proteins_show

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Protein information

Protein name Mitogen-activated protein kinase 7 
Synonyms EC 2.7.11.25
Transforming growth factor-beta-activated kinase 1
TGF-beta-activated kinase 1
TAK1
Gene name MAP3K7 , TAK1 .
Source Homo sapiens (Human)
Expression system Normal mouse hepatocyte cells (NMH)
Full length  606
Precursor  no
Mature form length  606
Molecular weight (Da)  67196
Swiss-Prot Sequence Version  June 1, 1998 (Sequence version 1)

Cross-references

Swiss-Prot/TrEMBL M3K7_HUMAN
PDB 2EVA .

Ubiquitylation features

Ubiquitylation site  
 

Ubiquitylation type Multiple ubiquitylation
Features TAK1 undergoes ubiquitylation and subsequent proteasomal degradation in response to TGF-beta1 treatment. That suppresses JNK activity through disruption of TAK1 signaling.

Ubiquitylation/deubiquitylation machinery

E2 Not determined
E3 XIAP
E4/AP Not determined
DUB Not determined
Comments XIAP modifies TAK1 mainly with K48-linked multiubiquitin chains. This may result in the protection of cells from TGF-induced apoptosis through inhibition of JNK activity.

References

[1]Kaur S, Wang F, Venkatraman M, Arsura M.
X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). J Biol Chem. 280(46):38599-608 (2005).
[16157589]

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